PINCHing together integrins and signaling
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چکیده
منابع مشابه
PINCHing together integrins and signaling
ancreatic  cells that exocytose insulin must make more insulin. Trajkovski et al., on page 1063, now demonstrate that the signal to induce insulin synthesis after exocytosis comes from the cleavage of the cy-toplasmic domain of islet cell autoantigen 512 (ICA512). This protein fragment migrates to the nucleus and drives changes in gene expression. Previous work showed that ICA512 is a transmem...
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The term integrin describes an adhesion molecule family and originates from the integrative function of these molecules between extracellular ligands and the intracellular cytoskeleton (1,2). Integrins mediate cell–cell, cell–extracellular matrix, and cell–pathogen interactions. Integrins have two major functions: First, they mechanically couple the cytoskeleton to the extracellular matrix or t...
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In their roles as major adhesion receptors, integrins signal across the plasma membrane in both directions. Recent structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways. Long-range conformational changes coupl...
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Dormant tumors awaken hat happens during tumor remission? After chemotherapy, tumor cell numbers may be reduced, or surviving cells may enter an altered, dormant state. Evidence for dormancy now comes from Catherine Shachaf, Dean Felsher (Stanford University, Stanford, CA), and colleagues. In their mouse model, liver tumors can be forced into dormancy and then reawakened at will. As in previous...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1676iti2